潜伏的多式联络特征与随访时类似精神病的经历有关
Eirini Zoupou1, Nicole R Karcher2, Joshua J Jackson1
1Department of Psychology, Washington University in St. Louis.
两个不同的青少年个人资料预测了持续的精神病样经历 (PLEs),表明了精神病的不同神经发育和情感风险路径. 这些发现有助于识别有风险的年轻人.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 发育神经科学的发展神经科学.
- 心理病理学研究 心理病理学研究
背景情况:
- 年轻人持续的,令人痛苦的精神病样经历 (PLEs) 与显著的损伤和精神病风险增加有关.
- 对于早期干预来说,区分这些与暂时的,非压力性的PLEs至关重要.
- 了解潜在因素可以为弱势青年提供有针对性的支持.
研究的目的:
- 确定基线潜伏概况,使持久性/压迫性PLE的年轻人与其他年轻人有区别.
- 为了确定基线个人资料会员是否预测了以后的精神病理和功能结果.
主要方法:
- 使用多种基线指标,对大量青少年队列 (N=11,724) 进行潜形状分析.
- 基于个人资料成员的基础上,一般化混合效应模型来预测后续结果.
主要成果:
- 两个关键的个人资料出现了,与更高的外部化症状和精神病家族史有关.
- 一个个人资料显示了更广泛的精神病理和情感失调;另一个人有低神经认知能力,精神分裂症样的大脑模式和社会经济劣势.
- 这两种概况都预测了随访时更持久,更令人痛苦的PLEs,具有共享和独特的结果关联.
结论:
- 这两种特征可能代表了不同的神经发育和情感途径,导致青少年患精神病的风险.
- 一个途径涉及认知和环境脆弱性;另一个途径涉及遗传风险,压力和情绪失调.
- 这些发现突显了精神病风险的异质性,并为个性化干预策略提供了信息.
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