针对异质人群进行个性化肺癌查建议:一项微观模拟研究
Joshua B Rager1,2,3, Pianpian Cao4, Rodney A Hayward5,6
1Division of General Internal Medicine and Geriatrics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Journal of the National Cancer Institute
|November 3, 2025
概括
个性化肺癌查 (LCS) 建议可以改善结果. 目前的指导方针可能会排除许多符合条件的经常吸烟者,他们可以从LCS中受益.
科学领域:
- 肺部医学 肺部医学
- 预防性健康 预防性健康
- 卫生经济学 卫生经济学
背景情况:
- 个性化肺癌查 (LCS) 建议是具有挑战性的,因为各种净益处.
- 探索净收益门可以指导个性化的LCS决策.
研究的目的:
- 探索LCS的净收益门对个人和人口的影响.
- 将个性化的LCS建议与当前的USPSTF指南进行比较.
主要方法:
- 微模拟用于在模拟的美国人口中 (年龄在40-80岁,经常吸烟者) 估计个人化质量调整后的生命年,以LCS节省.
- 确定了净收益门,考虑了患者的偏好和不确定性.
- 对比个性化的方法与USPSTF指导方针.
主要成果:
- 5900万模拟的美国成年人 (40-80岁,常吸烟者);1500万的USPSTF符合条件.
- 半数符合USPSTF资格的人群显示,LCS的净收益很高.
- 目前的标准不包括250万高净收益和2050万中等净收益的常吸烟者.
结论:
- 半个符合USPSTF资格的人口可以经常鼓励LCS.
- 目前的LCS资格标准可能会排除许多高净收益和中等净收益的常吸烟者.
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