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Updated: Jan 12, 2026

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
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Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

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结合RNA的化探针:G与醇色衍生物结合,用于选结合RNA的小分子

Ryosuke Nagasawa1,2, Kazumitsu Onizuka1,2,3, Ryohei Iwata1,2

  • 1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University Miyagi 980-8577 Japan onizuka@tohoku.ac.jp nagatugi@tohoku.ac.jp.

RSC chemical biology
|November 5, 2025
PubMed
概括

研究人员开发了新的RNA结合探针,TO-G,用于药物发现试验. 这些探针可以识别与RNA结合的独特小分子,改善查多样性和药物标识.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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