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Updated: Jan 12, 2026

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在ER+乳腺癌中,ESR1激活突变赋予了代谢脆弱性

Francesca Bonechi1, Marina Bacci2, Nicla Lorito1

  • 1University of Florence, Florence, Please select one, Italy.

Cancer research
|November 7, 2025
PubMed
概括

乳腺癌中的雌激素受体-1 (ESR1) 突变会在脂质代谢中产生脆弱性,使瘤对铁亡敏感. 将铁致死诱导剂与内分泌疗法的结合显示出治疗耐药ER+乳腺癌的前景.

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