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Updated: Jan 11, 2026

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综合致病变体,多基因风险评分和前列腺癌风险估计家族史在非洲祖先的男性.

Fei Chen1, Xin Sheng1, Anqi Wang2

  • 1Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

European urology
|November 11, 2025
PubMed
概括

生殖系致病变体 (PVs) 在非洲血统的男性中显著增加前列腺癌 (PCa) 风险. 结合PV状态,多基因风险评分 (PRS) 和家族史,完善了针对性查的PCa风险评估.

关键词:
非洲祖先的非洲血统.侵袭性前列腺癌是什么癌症倾向基因 癌症倾向基因终身绝对风险 终身绝对风险病原性变体 病原性变体多基因风险评分多基因风险评分.

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