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Updated: Jan 11, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Published on: July 17, 2020

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PTEN损失促进PI3Kβ酸化和EPHA2/SRC/p-PI3KβY962复合组合,以驱动瘤发生

Shuang Tang1, Qian Zhou2, Johann S Bergholz3

  • 1Fudan University Shanghai Cancer Center, Shanghai, China.

Cancer discovery
|November 14, 2025
PubMed
概括

失去PTEN瘤抑制剂导致癌症生长. 我们发现了一个新的基化PI3Kβ (p-PI3KβY962),对PTEN缺乏瘤至关重要,为治疗提供了一个新的治疗策略.

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