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相关概念视频

Lineage Commitment01:21

Lineage Commitment

4.1K
Commitment is the  process whereby stem cells:
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.2K
Histone Modification02:32

Histone Modification

15.9K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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相关实验视频

Updated: Jan 10, 2026

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors
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Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

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B-系的承诺取决于可逆的表观遗传开关.

Johanna Tingvall-Gustafsson1,2, Kim Hellerstedt1, Jonas Ungerbäck2

  • 1Department of Biomedical and Clinical Sciences, Linköping University, 58185 Linköping, Sweden.

Genes & development
|November 20, 2025
PubMed
概括
此摘要是机器生成的。

早期B细胞发育涉及一个表观遗传开关,由转录因子驱动,使T细胞基因沉默. 这一过程通过抑制固有的T谱系潜力来确保B-淋巴结合.

关键词:
在B-淋巴细胞.表观遗传学是指表观遗传学.转录 转录 是一种转录.

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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相关实验视频

Last Updated: Jan 10, 2026

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

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科学领域:

  • 免疫学 免疫学 免疫学
  • 发展生物学 发展生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 了解B淋巴瘤发育需要了解转录因子网络和表观遗传调节.
  • 早期的淋巴细胞原始体具有多种血统的潜力,包括T细胞.

研究的目的:

  • 使用高分辨率DNA可访问性数据建模早期B细胞发育.
  • 为了研究转录因子和表观基因组在B-淋巴结合期间的相互作用.

主要方法:

  • 结合单细胞RNA测序 (SC-RNA) 和骨髓原始种群上的ATAC测序 (SC-ATAC).
  • 趋势变化分析,以识别开发过程中DNA可访问性的变化.

主要成果:

  • 基于DNA可访问性变化,建立了B细胞发育的高分辨率模型.
  • 发现了一种快速的表观遗传切换,导致T系原始化的丧失和B淋巴细胞表观基因组的获取.
  • 这种切换与关键B系转录因子 (Ebf1,Pax5) 的激活相关.

结论:

  • 乙淋巴结合是由转录因子驱动的,剂量依赖的表观遗传开关介导的.
  • 表观遗传沉默对于维持B细胞命运至关重要,正如EZH1/EZH2抑制研究所证明的那样.
  • 这种开关抑制了早期淋巴细胞原始体内固有的T系潜力.