交叉复制母亲健康和自闭症之间的关联
Vahe Khachadourian1, Meredith Anderson2, Elias Speleman Arildskov3
1NYU Grossman School of Medicine, New York, New York.
Journal of the American Academy of Child and Adolescent Psychiatry
|November 23, 2025
概括
在美国的一项研究中,怀孕期间母亲的健康状况与自闭症风险有关,复制了丹麦队列的研究结果. 这表明这些关联在不同的人群和医疗保健环境中都很相关.
科学领域:
- 神经发育障碍 神经发育障碍
- 生殖健康 生殖健康
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,起源于早期的生活.
- 怀孕期间母亲的健康状况是影响自闭症风险的潜在因素.
- 以前关于母亲健康和自闭症风险的研究往往仅限于单个人群,这阻碍了概括性.
研究的目的:
- 调查先前报告的母亲健康状况与自闭症风险之间的关联的概括性.
- 为了比较来自美国队列的发现与丹麦基于登记册的研究.
主要方法:
- 在北加利福尼亚州凯泽永久医院 (KPNC) 分析了2010-2017年间出生儿童的电子健康记录.
- 母亲诊断的分类为慢性或非慢性.
- 使用考克斯模型来评估母亲诊断和儿童自闭症之间的关联,调整社会人口统计因素,医疗保健利用率和并发性母亲诊断.
- 方法与先前的丹麦研究对齐,以实现可比性.
主要成果:
- 在224,353名儿童中,2.4%被诊断为ASD.
- 在丹麦的42个与自闭症相关的母亲诊断中,38个可以在KPNC队列中进行评估.
- 在美国队列调整后,18个母亲诊断仍然具有统计学意义.
- 大多数协会的点估计结果与丹麦研究结果一致,特别是在精神病和心脏代谢疾病方面.
结论:
- 在丹麦的一项研究中发现,母亲健康状况与自闭症相关的显著比例 (38分之35) 在美国队列中得到了定性复制.
- 这些发现表明,母亲健康状况作为自闭症谱系障碍的潜在风险因素具有强大的交叉相关性.
- 需要进一步的研究来阐明潜在的生物机制,并确定潜在的效果修饰剂.
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