Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Immunoprecipitation01:20

Immunoprecipitation

8.0K
Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
8.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Interpretable Deep Learning for Single-Molecule Nanopore Fingerprinting Using Physics-Guided Preprocessing.

ACS sensors·2026
Same author

MicroRNA spatial profiling for assessing drug efficacy in <i>BRCA1</i> -related triple-negative breast tumors.

bioRxiv : the preprint server for biology·2026
Same author

Gradient-based optimization of complex nanoparticle heterostructures enabled by deep learning on heterogeneous graphs.

Nature computational science·2025
Same author

Surface-Mediated Self-Assembly of Kinetoplast DNA: Depletion-Driven Dimer Formation and Quasi-2D Dynamics.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Phase behavior of catenated-linear DNA mixtures.

Soft matter·2025
Same author

Data-driven organic solubility prediction at the limit of aleatoric uncertainty.

Nature communications·2025
Same journal

Zein-Ceria Hybrid Microparticles Enable Long-Term ROS-Scavenging Oxygenation for Osteogenic Microtissues Engineering.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Toward Practical Solid-State Lithium Batteries With High-Nickel Cathodes: An Interface-Centered Perspective.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

A Planarity-Hindrance Co-Balance Strategy to Develop Antiparallel H-Aggregates With Minimal Absorbance Blueshift for Type I Photodynamic Therapy.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Exceptional Rare-Earth Half-Heusler Thermoelectrics With Sublattice Softening.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Co-Assembled Hybrid Interlayer Engineering for Enhanced Upper Interface Stability in Inverted Perovskite Solar Cells.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Impact-Resistant Hydrogels Via Quaternary Ammonium-Regulated Networks.

Advanced materials (Deerfield Beach, Fla.)·2026
查看所有相关文章

相关实验视频

Updated: Apr 12, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.9K

通过基于溶剂的脱水来制备高度抗体.

Talia Zheng1, Lucas Attia1, Janet Teng1

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

Advanced materials (Deerfield Beach, Fla.)
|November 24, 2025
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的水性配方工艺,通过皮下注射提供高度抗体. 该方法可以在360 mg/mL时获得稳定,可注射的抗体微粒,从而改善生物管理.

关键词:
无形材料是无形的材料.抗体是一种抗体.这种水凝是水凝.降水 降水 降水 降水 降水通过皮下注射进行皮下注射.

更多相关视频

Activated Cross-linked Agarose for the Rapid Development of Affinity Chromatography Resins - Antibody Capture as a Case Study
07:53

Activated Cross-linked Agarose for the Rapid Development of Affinity Chromatography Resins - Antibody Capture as a Case Study

Published on: August 16, 2019

9.8K
Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
10:35

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

3.9K

相关实验视频

Last Updated: Apr 12, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.9K
Activated Cross-linked Agarose for the Rapid Development of Affinity Chromatography Resins - Antibody Capture as a Case Study
07:53

Activated Cross-linked Agarose for the Rapid Development of Affinity Chromatography Resins - Antibody Capture as a Case Study

Published on: August 16, 2019

9.8K
Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
10:35

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

3.9K

科学领域:

  • 生物制药配方 生物制药配方
  • 药物输送系统是药物输送系统.
  • 材料科学是一种材料科学.

背景情况:

  • 对于生物药物,皮下 (SC) 输送是首选的,但需要高度抗体配方.
  • 高度抗体溶液存在不稳定性和高粘度问题.
  • 现有的方法,如非水性溶液或水凝微粒具有局限性.

研究的目的:

  • 开发一种新的配方工艺,用于高度抗体水凝微粒的SC交付.
  • 为了在水系统中达到与非水性配方可比的抗体度.
  • 为了确保微粒内的抗体的结构和功能稳定性.

主要方法:

  • 使用基于溶剂的脱水方法将抗体度和封装成水凝微粒.
  • 连续的微粒子合成与同时脱水和抗体沉.
  • 分析抗体相位行为和沉-脱水动力学.

主要成果:

  • 开发了一种水性颗粒悬浮液,其配方度为360 mg/mL.
  • 在后处理和4个月后,抗体在结构和功能上保持稳定.
  • 达到临床上可接受的注射性,滑动力<20N.

结论:

  • 提出了第一个适用于SC施用的高度水性抗体配方.
  • 这种新的配方过程克服了现有的高度输送方法的局限性.
  • 该过程是各种SC生物应用的潜在平台.