幽灵折叠:使用结构受约束的合成共进化信号准确预测蛋白质结构

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Updated: Jan 10, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

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Nitesh Mishra1,2, Bryan Briney1,2,3,4,5

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037 USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

GhostFold从单个序列生成合成多重序列对齐 (伪MSA),使缺乏同类蛋白质的蛋白质能够准确预测蛋白质结构. 这种方法绕过了传统的数据库搜索,提供了一个计算效率高的解决方案.

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