2型糖尿病中的感觉网络调节障碍:连接嗅觉,视觉和认知功能
Qian Li1, Xin Li1,2,3, Yan Bi4
1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Diabetes, obesity & metabolism
|November 25, 2025
概括
嗅觉功能障碍显著地将多感官障碍与2型糖尿病 (T2D) 的认知衰退联系在一起. 保护感官网络可以支持T2D患者的认知和嗅觉健康.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是指老年学的学科.
背景情况:
- 2型糖尿病 (T2D) 与多感官和认知障碍有关.
- 嗅觉功能障碍是T2D的一个常见并发症.
- 在T2D中,感官缺陷和认知衰退之间的相互作用需要进一步研究.
研究的目的:
- 研究视觉,体感和嗅觉功能障碍与T2D认知衰退之间的关系.
- 检查嗅觉功能障碍在这种关系中的调解作用.
- 探索糖尿病外围神经病变 (DPN) 对这些关联的影响.
主要方法:
- 休息状态的fMRI被用来评估152名T2D患者和50名对照者的感觉皮层和区域大脑活动的功能连接.
- 开发了一种多感官功能障碍指数 (MSDI) 来量化综合感官功能障碍.
- 适度调解分析检查了感官并发症对认知功能的影响 (MoCA).
主要成果:
- MSDI与感官并发症负担相关,并预测了更差的全球认知表现 (MoCA).
- 气味识别调解了T2D患者MSDI和MoCA之间的联系.
- 这种调解在糖尿病外围神经病变 (DPN) + 患者中不存在,但在DPN-患者中显著,其中嗅觉功能障碍也对认知有直接影响.
结论:
- 嗅觉功能障碍在将多感官障碍与T2D的认知衰退联系起来方面发挥着核心作用.
- 管理策略应考虑个体感官并发症.
- 保持感官网络的完整性可能对保持T2D的嗅觉和认知健康至关重要.
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