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相关概念视频

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
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Metabolism of Chemolithotrophs01:15

Metabolism of Chemolithotrophs

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Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
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Overview of Metabolism01:40

Overview of Metabolism

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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
37.5K
¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons01:03

¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons

4.0K
Protons in identical electronic environments within a molecule are chemically equivalent and have the same chemical shift. The replacement test is a useful tool to identify chemical equivalence and predict NMR spectra. A substituent replaces each of the protons being examined and the resulting molecules are compared. If the same molecule is obtained, the protons are equivalent or homotopic. Replacement of any hydrogens in ethane by chlorine yields chloroethane because all six protons are...
4.0K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

15.0K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.0K
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

3.1K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
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相关实验视频

Updated: Jan 10, 2026

An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome
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An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome

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从所有视角学习:一种多视角对比框架用于代谢物注释.

Yan Zhou Chen1, Soha Hassoun1,2

  • 1Department of Computer Science, Tufts University, Medford, MA, 02155, USA.

bioRxiv : the preprint server for biology
|November 26, 2025
PubMed
概括

多视图投影 (MVP) 通过整合分子和光谱数据来增强代谢学. 这种新的框架提高了光谱注释率,推动了疾病研究和药物发现.

科学领域:

  • 代谢学 代谢学 代谢学
  • 计算化学的计算化学
  • 生物信息学是一种生物信息学.

背景情况:

  • 使用高通量质谱的代谢学对于理解细胞生物化学和疾病机制至关重要.
  • 由于光谱复杂性的低分子结构分配率阻碍了代谢学方面的进步.
  • 目前的方法很难有效地整合不同的数据视图来进行光谱注释.

研究的目的:

  • 引入多视图投影 (MVP),这是一个新的框架用于在代谢学中的光谱注释.
  • 开发一种学习分子和光谱之间的联合嵌入空间的方法.
  • 为了提高分子结构识别从质谱数据的准确性和稳定性.

主要方法:

  • MVP采用了对比的多视图学习,整合了分子图,指纹,光谱和共识光谱.
  • 该框架通过在多个数据视图中捕获相互信息来学习联合嵌入空间.
  • MVP支持使用个人或共识谱的灵活注释.

主要成果:

  • MVP通过从所有数据视图中共同学习,显著提高了分子候选者排名.
  • 使用MVP共识光谱的注释优于排名聚合策略.
  • 使用共识光谱,MVP在基于大规模的检索中获得了35.99%的排名@1,在基于公式的检索中获得了13.96%.

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相关实验视频

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics

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Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

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结论:

  • MVP提供了一种灵活和可扩展的基础,用于在代谢学中的光谱注释.
  • 该框架增强了质谱学在疾病机制和药物开发研究方面的潜力.
  • 通过MVP促进的更好的光谱注释率可以加速个性化医疗倡议.