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相关概念视频

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
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Metabolism of Chemolithotrophs01:15

Metabolism of Chemolithotrophs

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Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
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Overview of Metabolism01:40

Overview of Metabolism

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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
39.3K
¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons01:03

¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons

4.2K
Protons in identical electronic environments within a molecule are chemically equivalent and have the same chemical shift. The replacement test is a useful tool to identify chemical equivalence and predict NMR spectra. A substituent replaces each of the protons being examined and the resulting molecules are compared. If the same molecule is obtained, the protons are equivalent or homotopic. Replacement of any hydrogens in ethane by chlorine yields chloroethane because all six protons are...
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Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

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The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
17.1K
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

3.4K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
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相关实验视频

Updated: Feb 24, 2026

An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome
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An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome

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从所有视角学习:一种多视角对比框架用于代谢物注释.

Yan Zhou Chen1, Soha Hassoun1,2

  • 1Department of Computer Science, Tufts University, Medford, Massachusetts 02155, United States.

Analytical chemistry
|February 23, 2026
PubMed
概括

一个新的框架,多视图投影 (MVP),通过联合分析分子和光谱数据来增强代谢物识别. 这种方法提高了光谱注释的准确性,促进了疾病研究和药物发现.

科学领域:

  • 代谢学 代谢学 代谢学
  • 计算化学的计算化学
  • 生物信息学是一种生物信息学.

背景情况:

  • 使用高通量质谱的代谢学对于理解细胞生物化学,疾病机制,药物开发和个性化医学至关重要.
  • 低的光谱注释率是由于将分子结构分配到测量的光谱的挑战,阻碍了代谢学方面的进步.

研究的目的:

  • 引入多视图投影 (MVP),这是一个新的框架,旨在提高在代谢学中的光谱注释率.
  • 通过整合多个数据视图,为分子和光谱创建一个联合嵌入空间.

主要方法:

  • MVP使用对比的多视图学习来捕捉不同数据视图的相互信息:分子图,分子指纹,光谱和共识光谱.
  • 该框架从所有视图中共同学习,与以前使用连接或辅助任务的方法不同.
  • MVP支持使用个人频谱或共识频谱的灵活注释.

主要成果:

  • MVP显著改善了用于光谱注释的分子候选排名.
  • 使用MVP的查询共识光谱进行注释,优于基于构成频谱注释的排名聚合策略.
  • 在使用共识光谱进行基于公式的检索中,MVP 实现了 36.0% 的 rank@1 量级检索和 14.0%.

结论:

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  • MVP提供了一个灵活和可扩展的基础,用于从多个分子/光谱数据视图中学习.
  • 该框架的性能优于或与现有的光谱注释方法相提并论.
  • 通过MVP促进的更好的注释率可以加速在代谢学相关领域的发现.