从CMS到ICMS/IMF:发展通往结肠直肠癌精密治疗的路线图
Sungwon Jung1,2
1Department of Genome Medicine and Science, Gachon University College of Medicine, Incheon 21565, Republic of Korea.
International journal of molecular sciences
|November 27, 2025
概括
内在亚型MSI纤维化 (IMF) 系统完善了结直肠癌 (CRC) 的分类和治疗策略. 这一框架整合了分子亚型,MSI状态和纤维化,用于准确的治疗决策.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 结肠直肠癌 (CRC) 的分类从共识分子亚型 (CMS) 演变为上皮内在亚型 (iCMS) 和分层内在亚型-MSI-纤维化 (IMF) 系统.
- 国际货币基金组织系统整合了固有分子状态,微卫星不稳定性 (MSI) 状态和瘤纤维化,以进行全面的分类.
研究的目的:
- 审查ICMS/IMF的生物基础,它们与瘤微环境 (TME) 交叉通话的联系,以及高级转录组学的作用.
- 通过分析TME异质性和纤维化,探索单细胞和空间转录组学如何增强治疗分层.
- 概述预后和治疗影响,包括免疫疗法,向疗法和基于纤维化轴的决策点.
主要方法:
- 对iCMS/IMF,TME交叉通话和转录技术的现有文献的审查.
- 分析单细胞和空间转录组学如何解决TME异质性及其对纤维化的影响.
- 整合病理学,分子诊断和精准医学治疗映射.
主要成果:
- 国际货币基金组织系统为了解CRC生物学和TME相互作用提供了一个精细的框架.
- 单细胞和空间转录组学为TME异质性及其对纤维化的影响提供了更深入的见解.
- 针对高MSI,BRAF突变和RAS野生型瘤,IMF系统提供了特定的治疗策略.
结论:
- 国际货币基金组织 (ICMS) /国际货币基金组织 (IMF) 的框架促进了可重复分类,并加强了结直肠癌的精准医学.
- 将病理学,分子诊断和治疗映射与先进的成像和治疗方法相结合,为未来的CRC治疗提供了路线图.
- 未来的研究应该专注于微卫星稳定的ICMS3和高纤维化瘤的生物标志物药物假设,以推进临床翻译.
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