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Updated: Aug 1, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
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通过泛基MHC-I点突变连体组评估评估,评估训练可概括的基于序列的TCR特异性模型的数据大小要求

Antoine Delaunay1, Miles McGibbon2, Bachir Djermani3

  • 1InstaDeep Ltd, 5 Merchant Sq, London, UK. a.delaunay@instadeep.com.

Scientific reports
|November 27, 2025
PubMed
概括

开发个性化的T细胞受体 (TCR) 疗法需要预测TCR-neoepitope结合. 当前的机器学习模型需要数以百万计的数据点进行概括,远远超过有效的瘤治疗的可用数据.

关键词:
在瘤学瘤学.个性化的T细胞疗法样本大小估计 样本大小估计预测TCR特异性的预测

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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...