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Updated: Jan 9, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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SM08502介导的β-卡铁因抑制与olaparib协同作用,以抑制瘤进展

Bradley R Corr1, Elizabeth R Woodruff2, Tomomi M Yamamoto2

  • 1Division of Gynecologic Oncology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

Cancer research communications
|December 4, 2025
PubMed
概括

一种新型药物SM08502 (cirtuvivint),与PARP抑制剂 (PARPi) 结合,在卵巢癌模型中显示出克服对PARPi治疗的抗性. 这种组合疗法减少了瘤的进展,并通过准WNT信号和重塑瘤免疫微环境来改善存活率.

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