Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.8K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.8K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Traffic State Lane-Level Estimation Based on Transformer and Vehicle Trajectory Data.

Sensors (Basel, Switzerland)·2026
Same author

Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour.

Nature cell biology·2026
Same author

Trajectory planning for traffic safety with dynamic ethical risk adjustment.

Accident; analysis and prevention·2026
Same author

A unified risk metric for freeway vehicles based on the spatio-temporal overlap probability of predicted positions.

Accident; analysis and prevention·2025
Same author

DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma.

Molecular cancer·2025
Same author

Risk quantification based Adaptive Cruise control and its application in approaching behavior at signalized intersections.

Accident; analysis and prevention·2025

相关实验视频

Updated: Jan 9, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.4K

瘤启动干细胞设计免疫系统.

Zhe Yang1, Linheng Li2

  • 1Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

Cancer cell
|December 5, 2025
PubMed
概括
此摘要是机器生成的。

高SOX2的癌症干细胞重编程中性粒细胞,阻碍免疫治疗的有效性. 这些重编程的中性粒细胞在瘤-肌瘤界面保持着亲瘤状态,影响治疗结果.

更多相关视频

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

7.6K
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.9K

相关实验视频

Last Updated: Jan 9, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.4K
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

7.6K
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.9K

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 癌症干细胞生物学

背景情况:

  • 免疫治疗的有效性通常受到瘤微环境的限制.
  • 癌症干细胞 (CSCs) 在瘤复发和治疗耐药性方面发挥着至关重要的作用.
  • 瘤微环境中的CSC和免疫细胞之间的相互作用对治疗反应至关重要.

研究的目的:

  • 为了研究SOX2高的瘤发起干细胞如何影响免疫疗法期间的瘤微环境.
  • 确定CSCs逃避免疫监测并促进免疫治疗后瘤进展的机制.
  • 了解中性粒细胞在调解SOX2高CSC与免疫治疗之间的相互作用中的作用.

主要方法:

  • 利用具有高SOX2的瘤发起干细胞的癌症小鼠模型.
  • 在免疫治疗前后,在瘤微环境中分析了免疫细胞群,特别是中性粒细胞.
  • 通过转录组和蛋白组分析,研究了参与SOX2-高CSC-中性粒细胞相互作用的分子信号通路.

主要成果:

  • 发现高SOX2的瘤发起干细胞能够在瘤微环境中重编程中性粒细胞.
  • 重编程的中性粒细胞抑制了干扰素诱导的抗瘤反应,这对免疫疗法的有效性至关重要.
  • 这些中性粒细胞在瘤-肌瘤界面保持了亲瘤表型,支持CSC存活和瘤生长.

结论:

  • 高SOX2的CSC通过重编程中性粒细胞来积极操纵瘤的微环境.
  • 细胞核细胞对中性粒细胞进行重编程,是免疫疗法耐药性的重要机制.
  • 针对高SOX2的CSC-中性粒细胞轴可以提供新的治疗策略,以提高免疫治疗结果.