在阅读障碍症中重新审视非典型的语言侧面化.
Helena Verhelst1,2, Emma M Karlsson1,2, Robin Gerrits1,3
1Department of Experimental Clinical and Health Psychology, Ghent University, Ghent 9000, Belgium.
Brain communications
|December 8, 2025
概括
发育性阅读障碍与不一致的大脑横向化模式有关,而不是普遍较弱的模式. 区域大脑激活的这种不一致性可能会破坏语言网络,导致阅读困难.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 发展障碍 发展障碍 发展障碍
背景情况:
- 半球横向化是发展性阅读障碍研究中的一个长期关注点,但它的确切作用仍然不清楚.
- 之前的研究表明,与阅读障碍症中大脑不对称性改变有关的结果不一致,通常忽视了个体的变异性.
- 了解半球横向化模式对于阐明阅读和语言缺陷的神经生物学基础至关重要.
研究的目的:
- 为了研究与匹配的对照人群相比,患有阅读障碍的成年人半球横向化模式.
- 通过使用功能性MRI来评估不同语言任务中大脑激活的强度,方向和一致性.
- 探索横向化个体变异性与阅读障碍症阅读能力之间的关系.
主要方法:
- 功能性MRI (fMRI) 用于扫描35名阅读障碍成人和35名对照人群.
- 参与者完成了三个语言任务:单词生成,押决定和词汇决定.
- 横向性指数是为了分析全球和区域大脑激活模式而计算的.
主要成果:
- 在全球横向化绝对强度方面没有发现任何显著的群体差异.
- 阅读障碍症患者在阅读和合作业时,区域横向化的不一致性更大.
- 阅读障碍与较弱的状回旋侧面化和在阅读期间在该区域右半球激活的更高患病率有关.
结论:
- 发育性阅读障碍的特点是不一致的,而不是普遍较弱的半球横向化模式.
- 特定任务和区域横向化不一致可能会损害语言网络的效率,导致阅读缺陷.
- 考虑到横向化中的个体变异性对于理解阅读障碍和语言障碍的神经基础至关重要.
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