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Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Updated: Jan 9, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

弥合翻译差距:通过人类相关的体外模型重新思考动脉样硬化中的光滑肌细胞可塑性.

Liliana Som¹, Nicola Smart¹

¹Department of Physiology, Anatomy and Genetics, Institute of Developmental & Regenerative Medicine, BHF Oxford Centre of Research Excellence, University of Oxford, Oxford OX3 7TY, UK.

|December 10, 2025

概括

人类血管光滑肌细胞 (SMC) 的可塑性是动脉样硬化症的关键,但目前的模型错过了人类的复杂性. 本综述强调了在人体数据上验证的先进体外模型如何弥合这一知识差距.

关键词:

人类相关的人类相关.在体外建模 in vitro 建模俄米克斯 (omicsics) 是一个电子产品.现型性可塑性现型性可塑性顺肌细胞是平滑肌肉细胞.

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Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

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Published on: July 6, 2022

相关实验视频

Last Updated: Jan 9, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

科学领域:

心血管生物学心血管生物学
细胞可塑性细胞可塑性
动脉样硬化研究动脉样硬化研究

背景情况:

血管光滑肌细胞 (SMC) 的可塑性显著影响动脉样硬化进展.
现有的小鼠模型不充分地代表了与疾病相关的各种人类SMC表型.
由于模型的局限性,在理解人类SMC状态时存在一个翻译差距.

研究的目的:

审查和倡导改进的人体体外试验模型来研究SMC可塑性.
解决当前实验模型在捕捉人类SMC复杂性的局限性.
建议将先进的体外系统与人类体外科学数据相结合,以便更好地建模疾病.

主要方法:

对各种体外系统的批判性评估,包括单种植,共同种植和3D平台.
检查这些系统如何模拟人类的SMC可塑性.
强调对体外模型与人类单细胞和多细胞数据进行比较.

主要成果:

人类研究揭示了SMC表型的范围比目前建模的更广泛.
先进的体外模型为更好地回顾人类SMC可塑性提供了潜力.
对人类数据进行基准测试对于验证和完善实验模型至关重要.

结论:

弥合翻译差距需要人体体外试验模型,这些模型可以批判性地评估和整合omics数据.
根据人类数据选择和验证模型对于精确的动脉样硬化研究至关重要.
需要改进的人体体外试验模型,才能充分理解SMC在人类疾病中的可塑性.