Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.3K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.3K
Inflammatory Response01:28

Inflammatory Response

15.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.8K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.9K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.9K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.2K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.2K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.1K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.1K
Phases of Wound Repair01:28

Phases of Wound Repair

7.8K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
7.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Comparative Evaluation of Argon and Helium Plasma for Controlled Epidermal Peeling and Dermal Remodeling in Human Skin Tissue.

Aesthetic plastic surgery·2026
Same author

Comparative Analysis of Collagen Induction in Sprague Dawley Rat Model Using Absorbable Threads for Facial Lifting and Rejuvenation.

Aesthetic plastic surgery·2025
Same author

Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation.

Cells·2025
Same author

Clinical Application of a New Near-Infrared Light-Emitting Diode with Broader Spectrum for Skin Rejuvenation and Hair Growth Enhancement.

Aesthetic plastic surgery·2025
Same author

Development and Evaluation of an Injectable Acellular Dermal Matrix for Breast Reconstruction.

ACS applied bio materials·2025
Same author

Acellular Extracellular Matrix Scaffolds in Regenerative Medicine: Advances in Decellularization and Clinical Applications.

Journal of functional biomaterials·2025

相关实验视频

Updated: Jan 8, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

8.4K

一种天然复合材料提取物通过调节炎症,水合和逆氧化通路来恢复皮肤屏障功能.

Caijun Jin1,2, Youn Jeong Cha3, Hee Eun Kim4

  • 1Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea.

Journal of cosmetic dermatology
|December 13, 2025
PubMed
概括

一种植物性提取物PLCP有效地减少了儿童和成人角质细胞的皮肤炎症,和氧化应激. 这种提取物还增强了皮肤水分,显示了治疗儿科皮肤病的前景.

关键词:
索赔证明 索赔证明 索赔证明乳液是一种乳液,乳液是乳液.这是一种配方配方.皮肤障碍物 皮肤障碍物

更多相关视频

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

12.7K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.4K

相关实验视频

Last Updated: Jan 8, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

8.4K
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

12.7K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.4K

科学领域:

  • 皮肤病学和化品科学
  • 在体外皮肤生物学.
  • 基于植物的治疗方法

背景情况:

  • 儿科皮肤疾病通常涉及炎症,和氧化应激.
  • 目前的治疗方法可能有局限性,需要探索新的,安全的替代方案.
  • 植物衍生化合物越来越多地被研究为皮肤学应用.

研究的目的:

  • 评估一种新型复合植物提取物 (PLCP) 在关键皮肤健康参数上的疗效.
  • 评估PLCP对皮肤水分,炎症,和氧化应激的影响.
  • 调查皮质细胞对PLCP反应的潜在年龄相关差异.

主要方法:

  • 使用的儿科 (NHEK) 和成人 (HaCaT) 角质细胞,用脂多糖 (LPS) 刺激.
  • 评估PLCP对炎症 (TSLP,ET-1),,水合 (HAS) 和氧化应激 (ROS,SOD) 标志物的影响.
  • 使用rt-PCR,ELISA,ROS测定和SOD活动测量进行综合分析.

主要成果:

  • 在两种细胞类型中,PLCP显著抑制了LPS诱导的TSLP和ET-1分泌/mRNA水平.
  • 根据剂量,PLCP上调调节了氨酸合成酶 (HAS) mRNA,表明增强了水分.
  • 通过降低ROS和增加SOD活性,PLCP表现出强大的抗氧化作用.

结论:

  • 在实验室中,PLCP表现出显著的抗炎,抗,保湿和抗氧化特性.
  • 儿童角质细胞对PLCP的反应更加明显,这表明年龄特定的疗效.
  • PLCP为治疗儿科皮肤疾病提供了一个有希望的,安全的,基于植物的选择.