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用PASTA在空间转录学中准确地归纳特定途径的基因表达

Ruoxing Li1,2, Peng Yang1,3, Mauro Di Pilato4

  • 1Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature communications
|December 15, 2025
PubMed
概括

通过赋予通路基因表达,PASTA增强了空间转录学,提高了准确性和生物相关性. 这种方法利用细胞类型和空间近距离在疾病研究中提供更稳定的预测.

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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...