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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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相关实验视频

Updated: Jan 8, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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增加PRL-PitNETs的负担:跨瘤大小和偶然瘤的模式.

Frederik Østergaard Klit1,2,3, Sara Faartoft Nørgård1,2, Anna-Sofie Dam Berrett1,2

  • 1Department of Endocrinology, Aalborg University Hospital, 9000 Aalborg, Denmark.

European journal of endocrinology
|December 17, 2025
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此摘要是机器生成的。

益生素分泌的垂体神经内分泌瘤 (PRL-PitNETs) 变得越来越常见,男性的发病率越来越高,偶发性瘤的增加. 这一趋势表明疾病特征的转变以及医疗保健负担的增加.

关键词:
流行病学流行病学过高乳糖性血症是什么意思偶尔发生的瘤宏观腺瘤 宏观腺瘤孕产妇的前乳腺瘤是什么

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科学领域:

  • 内分泌学 在内分泌学.
  • 神经瘤学神经瘤学
  • 流行病学 流行病学

背景情况:

  • 关于前素分泌 pituitary神经内分泌瘤 (PRL-PitNETs) 的流行病学数据有限且不一致.
  • 在发病年龄,性别分布和瘤特征方面,PRL-PitNETs表现异质.

研究的目的:

  • 调查PRL-PitNETs的时间流行病学趋势.
  • 评估随着时间的推移,患病率,发病率和患者人口统计的变化.

主要方法:

  • 在北丹麦地区 (2017-2022) 使用ICD-10编码和治疗数据进行了一项队列研究.
  • 对已发表的研究 (PubMed,Embase) 进行了系统审查和元分析.
  • 分析的数据包括患者人口统计,瘤大小和益生菌素水平.

主要成果:

  • 队列研究显示,从2017年到2022年,PRL-PitNET流行率增加了41%.
  • 对15项研究 (16,000例) 的分析显示,PRL-PitNET患病率 (41/100,000) 和发病率 (2.3/100,000人/年) 的增加.
  • 观察到一种表型转变,在过去二十年中,男性,巨细胞瘤和偶发性瘤的比例更高.

结论:

  • PRL-PitNETs的患病率越来越高,受男性和偶发性瘤发病率上升的影响.
  • 这些流行病学转变表明疾病表型的变化以及临床和医疗保健需求的不断升级.