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Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

217
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

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Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

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The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
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Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
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[皮下输液:说明,实际考虑和耐受性]

Robin Arcani1, Julia George2, Florian Correard3

  • 1Service de médecine interne et thérapeutiques, CHU de la Timone, 264, rue Saint-Pierre, 13005 Marseille, France; Inra 1260, Inserm UMR_S 1263, Centre de recherche en cardiovasculaire et nutrition (C2VN), Aix-Marseille université, Marseille, France.

La Revue de medecine interne
|December 18, 2025
PubMed
概括

皮下输液是一种新兴的皮下溶解技术,为静脉注射提供了一种安全有效的替代方案,特别适用于老年人和息护理患者. 这种方法不那么侵入性,耐受性很好,并且适用于门诊机构.

关键词:
抗生素 抗生素是一种抗生素.抗生素 抗生素是一种抗生素.老年病的医生 老年病的医生一个年轻的家庭.水化是指水的含量.补水 补水 水分 补水 补水抚慰性护理是一项非常重要的护理.护理有缓解作用的治疗这就是所谓的sous-cutané.皮下使用 皮下使用 皮下使用

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科学领域:

  • 医疗管理医疗管理
  • 药理学 药理学是指药理学的学科.
  • 老年病的医生 老年病的医生

背景情况:

  • 皮下 (SC) 输液,或皮下溶解,涉及注射液体/药物到皮下.
  • 历史上使用,由于技术问题而被放弃,但在20世纪90年代恢复,特别是老年病和息治疗.
  • 静脉注射 (IV) 输注不那么侵入性,耐受性更好,比静脉注射 (IV) 更安全,门诊实施更容易.

研究的目的:

  • 审查现代医学中皮下输液的复苏和应用.
  • 为特定患者群体和临床场景突出其与静脉注射途径相比的优势.
  • 讨论下皮质溶解的药理动力学,适用情况和安全性概况.

主要方法:

  • 关于皮下输液的历史和最近研究的文献综述.
  • 对药物动力学数据的分析,比较SC和IV路径.
  • 检查临床指示和不良事件概况.

主要成果:

  • SC输注的吸收速度略低于IV,但水溶性化合物的生物利用率往往超过80%.
  • 关键的适应症包括脱水管理,息治疗 (止痛药,抗焦虑药) 和特定的抗生素 (塞夫特里亚克松,埃尔塔佩内姆,提克普拉宁).
  • 局部不良事件通常是轻微的和短暂的;感染是罕见的,支持它的安全性.

结论:

  • 低皮质解剖是一种安全,实用的替代方案,特别适用于老年/脆弱患者,解决门诊医疗需求和医院拥挤问题.
  • 更广泛的采用需要加强医疗保健专业人员的培训,标准化的协议和更多的比较数据.
  • 它在治疗脱水,提供息护理药物和使用某些抗生素方面的有效性得到了充分的支持.