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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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相关实验视频

Updated: Jan 8, 2026

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
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技术与痴呆症 会议前会议

Laura M Rueda-Delgado1, Florentine M Barbey1, Alison R Buick2

  • 1Cumulus Neuroscience, Dublin, Ireland.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括

使用NeuLogiq平台进行的数字认知评估显示,与传统方法相比,在检测阿尔茨海默病进展方面,敏感度更高. 这些家庭测试为痴呆症更强大,更有效的临床试验提供了潜力.

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科学领域:

  • 神经科学是一个神经科学.
  • 临床试验 临床试验
  • 数字健康数字健康

背景情况:

  • 阿尔茨海默病 (AD) 临床试验需要敏感的进展检测,这是由于老化和不敏感的传统评估 (例如,ADAS-Cog) 等混因素而具有挑战性.
  • 基于家庭的多模式数字评估提供了一个潜在的解决方案,以提高痴呆症临床试验的敏感性和效率.

研究的目的:

  • 评估使用NeuLogiq平台对阿尔茨海默氏症痴呆患者在12个月内在家中进行重复的多模式数字评估的可行性和价值.
  • 量化数字测量与检测疾病进展的传统终点相比,数字测量的统计能力.

主要方法:

  • 一项非干预性研究,涉及59名轻度痴呆症患者和60名英国七个地点的对照.
  • 参与者在家中使用同步低负荷EEG平板电脑执行8项认知任务,每项任务在52周内进行26个样本.
  • 定期收集基准评估 (ADAS-Cog) 和血;使用混合效应模型分析进展情况.

主要成果:

  • 虽然ADAS-Cog等传统测量方法显示出适度的进展差异,但两种NeuLogiq数字测量方法显示出显著更高的灵敏度:基于平板电脑的关联记忆任务和心理运动任务.
  • 这些数字任务显示出比ADAS-Cog更大的效果大小,并且在多次比较中经过了校正.
  • 后期分析表明,数字任务可以根据p-tau状态和执行功能来区分患者.

结论:

  • 在家中自主执行的个人基于平板电脑的认知任务比ADAS-Cog.更敏感地衡量阿尔茨海默病的进展.
  • 数字评估有望增加统计能力,减少痴呆症临床试验的规模,持续时间和风险.