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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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阿尔茨海默氏症成像联盟

Natasha V Stevanovich1, Robert Stewart2,3, Dag Aarsland1,2

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概括
此摘要是机器生成的。

社会经济贫困与脑容量减少有关,特别是在海马和杏仁体,在认知障碍患者中. 这表明,剥夺可能会增加对神经退行症的脆弱性.

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科学领域:

  • 神经科学是一个神经科学.
  • 放射学 放射学是一门学科.
  • 公共卫生 公共卫生

背景情况:

  • 社会经济贫困与痴呆症风险因素以及海马和杏仁体等关键区域的大脑体积减少有关.
  • 之前的研究没有在现实世界认知障碍人群中检查这些关联.
  • 机器学习现在允许从临床MRI中详细分析较小的大脑结构.

研究的目的:

  • 研究具有认知障碍的患者的社会经济贫困和特定大脑体积 (整个大脑,海马体,海马子领域,杏仁体) 之间的关联.
  • 利用先进的机器学习技术来可视化和量化这些大脑结构.
  • 探索贫困在区域神经退行症脆弱性中的作用.

主要方法:

  • 利用来自南伦敦和莫德斯利 (SLaM) 图像银行的MRI扫描用于被诊断为MCI/痴呆症亚型的患者.
  • 获得的英国多重剥夺指数 (IMD) 评分和可修改的痴呆风险因素 (高血压,糖尿病,脑血管事故,喘) 数据.
  • 采用多个线性回归模型,调整混因子,并使用ANTsX管道与DSK图谱进行大脑结构体积分析.

主要成果:

  • 包括3075名患者 (平均年龄77岁,58%的女性,40%的少数民族) 诊断包括阿尔茨海默病 (AD) 和轻度认知障碍 (MCI).
  • 在所有认知障碍类型中,更高的IMD得分 (更大的剥夺) 与海马和杏仁体体积的减少显著相关.
  • 在海马子领域 (例如,CA1),准海马回环,外围皮质和杏仁体中注意到了特定的减少,在AD和MCI组中最强烈的关联.

结论:

  • 较高的社会经济贫困与具有认知障碍的个体中明显的海马子和杏仁体缩有关.
  • 社会经济贫困可能在区域对神经退行症的脆弱性中发挥着比以前认为的更重要的作用.
  • 这些发现突出了社会经济因素对大脑健康和神经退行过程的影响.