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阿尔茨海默氏症成像联盟

Jay J Pillai1, Robert I Reid1, Stephen D Weigand1

  • 1Mayo Clinic, Rochester, MN, USA.

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概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的等离子体生物标志物与通过神经元导向分散和密度成像 (NODDI) 检测到的大脑微观结构变化相关. 这支持NODDI在评估认知衰退方面的应用.

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科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物 生物标志物
  • 神经退行发生神经退行.

背景情况:

  • 血神经丝光链 (NfL) 和质纤维酸蛋白 (GFAP) 在阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 中升高.
  • 神经元定向分散和密度成像 (NODDI) 使用扩散MRI评估轴突和树突微结构.
  • 时间皮层NODDI测量与认知衰退中的血生物标志物之间的关联尚未得到充分证实.

研究的目的:

  • 评估时间皮层NODDI衍生的测量 (ODI,NDI,ISOVF) 与血NfL和GFAP度之间的关联.
  • 研究NODDI在评估与认知衰退相关的皮质微结构变化的有用性.

主要方法:

  • 包括来自梅奥诊所衰老研究 (MCSA) 和阿尔茨海默氏症痴呆症研究中心 (ADRC) 的认知不受损 (CU),MCI或痴呆症诊断的参与者 (60-95岁).
  • 在3T西门子镜扫描仪上获得NODDI成像,并使用Simoa®神经学4-Plex E Advantage套件测量了血NfL和GFAP.
  • 使用线性回归模型,调整年龄,性别,BMI,皮质厚度/体积和总内体积,以评估区域NODDI测量和日志转换血度之间的关系.

主要成果:

  • 在多个叶区域 (包括海马体,杏仁体和脑内皮层) 中观察到血NfL度和神经元密度指数 (NDI) 之间存在显著的反向关系.
  • 在所有评估区域中,较高的NfL度与较高的同位素体积分数 (ISOVF) 有关.
  • 在对共变量进行调整后,NDI和NfL之间仍然存在显著的关联,特别是在海马和杏仁体区域.

结论:

  • 在叶皮层区域的NODDI衍生测量 (NDI和ISOVF) 与轴突和星细胞功能障碍的血生物标志物有显著的关联.
  • 这些发现为使用NODDI来评估与阿尔茨海默病认知衰退相关的皮质微结构变化提供了初步验证.