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基于结构的药物设计中的蛋白质结晶策略.

Margareta Ek1, Linda Öster1, Helena Käck1

  • 1Protein Science, Structure and Biophysics, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Expert opinion on drug discovery
|December 24, 2025
PubMed
概括

为药物设计开发可靠的蛋白质 - 连接体晶体结构具有挑战性. 本综述提供了强大的结晶工作流程和在标准方法失败时基于结构的药物设计的救援策略.

关键词:
这是FBLGG.蛋白质结晶的过程中的蛋白质结晶.共同结晶的结晶化发现药物的发现.蛋白质 - 配体复合物中的蛋白质 - 配体复合物.浸泡浸泡浸泡浸泡浸泡浸泡浸泡浸泡浸泡浸泡基于结构的药物设计.

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