临床表现 临床表现
Glenda Dias Dos Santos1, Orestes Vicente Forlenza2,3,
1Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
认知障碍影响15%的COVID-19幸存者,影响记忆,注意力和语言在住院24个月后. 早期识别对于区分这些缺陷与其他神经疾病至关重要.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 传染病研究 传染病研究
背景情况:
- COVID-19幸存者经常报告认知障碍,导致功能限制和生活质量下降.
- 在中度至重度的COVID-19疾病后,很大一部分人经历了持续的认知缺陷.
研究的目的:
- 评估COVID-19幸存者队伍中认知障碍的流行程度和性质.
- 在经历中度或重度COVID-19的个体中调查长期认知后果.
主要方法:
- 361名成年COVID-19幸存者在医院出院24个月后被评估.
- 一个全面的认知电池包括迷你精神状态检查,CERAD电池,Trail Making Test (A和B) 和数字跨度测试.
主要成果:
- 15% (54名成年人) 在各个领域表现出认知缺陷.
- 在口头流利 (48.1%),命名 (74%),单词列表回忆 (83.3%),执行功能 (Trail Making Test, 66.7%) 和工作记忆 (Digit Span, 53.7%) 中发现了障碍.
- 在认知测试表现,年龄和迷你精神状态检查得分之间发现了显著的相关性.
结论:
- 认知电池有效地确定了COVID-19幸存者的执行功能,记忆,注意力和语言的缺陷.
- 建立特定的认知缺陷模式对于区分COVID-19相关损伤与其他类型痴呆症至关重要.
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