生物标志物 生物标志物
Jacklyn Leonardo1, Gurveen Kaur Sandhu1, Ashwati Vipin2
1Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
血管因素在东南亚人中显著影响痴呆症生物标志物,观察到更高的粉样蛋白负担,GFAP,NfL和pTau181. 特定区域的研究对于了解不同人群中痴呆风险至关重要.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 人口健康 人口健康
背景情况:
- 痴呆症研究主要集中在西方人群上,忽视了东南亚的种族多样性.
- 新加坡独特的多民族人口 (中国人,马来人,印度人) 为研究痴呆风险因素提供了机会.
- 在了解东南亚人口,遗传和白质对血液生物标志物的影响方面存在差距.
研究的目的:
- 调查人口,遗传和大脑白质对新加坡血基痴呆症生物标志物的影响.
- 为了将东南亚队列中的痴呆症生物标志物概况与西方队列进行比较.
主要方法:
- 来自新加坡生物标志物和认知研究 (BIOCIS) 的1646名参与者的分析.
- 根据认知状态的分层 (认知无障碍,轻度认知障碍),年龄,性别,种族,APOE ε4状态,Fazekas得分和Staals得分.
- 血生物标志物 (Aβ40,Aβ42,GFAP,pTau181,NfL) 的组间和与西方MCI队列之间的比较.
主要成果:
- 在认知不受损的个体中,Fazekas阳性与改变的生物标志物相关 (不包括Aβ42 / 40比率).
- 在轻度认知障碍中,血管负担 (Fazekas/Staals阳性) 与高GFAP,pTau181和NfL相关.
- 与西方队列相比,BIOCIS MCI队列表现出较低的粉样蛋白负担和APOE4阳性,但较高的白质超强度.
结论:
- 法泽卡斯的阳性影响了东南亚人的痴呆症生物标志物概况,强调了血管贡献.
- 在MCI组中的血管负担表明对生物标志物概况的持续影响.
- 独特的生物标志物概况需要区域特定的研究,以改善东南亚的痴呆症诊断和护理.
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