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在工作内存维护中的异步启动和关闭状态
Rana Mozumder1, Zhengyang Wang2, Wenhao Dang1
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Cell reports
|December 25, 2025
概括
工作记忆可能依赖于异步的神经状态,而不是持续的尖. 分布的模式波动,影响前额外皮层和顶层皮层的信息保真度.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 工作记忆对于认知至关重要.
- 提出了两个主要的神经机制:持续的尖端活动和活动静音机制.
- 了解它们的相对贡献是理解记忆功能的关键.
研究的目的:
- 通过检查持久活动和活动静音机制来研究工作记忆的神经相关性.
- 确定这些机制在侧面前额皮层 (LPFC) 和后壁皮层 (PPC) 的相对贡献.
主要方法:
- 在使用高密度微电极的中记录LPFC和PPC的神经活动.
- 分析了记忆信息中的持续延迟活动和时间波动.
- 评估神经群体的解码精度.
主要成果:
- 在前额神经元中观察到平均持久延迟活动,但静默时期与偶然性没有显著差异.
- 活动依赖的记忆信息存在时间波动,LPFC和PPC之间存在弱相关性.
- 与伪人口相比,同时记录的神经元的解码精度降低了.
结论:
- 结果支持工作记忆的异步状态.
- 工作记忆是通过分布式活动模式来维持的.
- 这些模式受到广泛分布的波动的影响,影响信息表示忠实度.
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