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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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生物标志物 生物标志物

Panpan Shen1, Sheng Zhang2, Yu Geng2

  • 1Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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PubMed
概括
此摘要是机器生成的。

通过OCTA测量的辐射周周毛细管 (RPC) perfusion 区域可以帮助区分血管痴呆症 (VaD) 与血管轻度认知障碍 (VMCI). 这种视网膜生物标志物在内动脉狭窄症 (ICAS) 患者的早期检测方面表现有前途.

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科学领域:

  • 眼科和神经病学 眼科和神经病学
  • 神经成像和血管疾病

背景情况:

  • 内动脉狭窄 (ICAS) 与血管认知障碍 (VCI) 有关.
  • 在ICAS患者中确定可靠的VCI生物标志物对于早期干预至关重要.
  • 视网膜微血管变化可能反映出潜在的脑血管病理.

研究的目的:

  • 调查视网膜和冠状腺微血管参数作为ICAS患者VCI的潜在生物标志物.
  • 评估光连贯断层扫描血管学 (OCTA) 在区分血管轻度认知障碍 (VMCI) 和血管痴呆症 (VaD) 的诊断能力.

主要方法:

  • 招募了123名无症状ICAS患者,并分为VMCI和VaD组.
  • OCTA用于测量视网膜层中的血管密度和 perfusion 区域.
  • 还评估了MRI中的脑小血管疾病 (CSVD) 生物标志物.

主要成果:

  • 辐射周毛细血管 (RPC) perfusion 区域与 VaD 有正相关.
  • CSVD负荷得分和白质超强度 (WMH) 量与VaD负相关.
  • 与CSVD和WMH相比,受影响眼睛的RPC perfusion区域对VaD与VMCI的区分能力更强.

结论:

  • 在ICAS患者中,OCTA衍生的RPC输液区域是VaD和VMCI之间的有效区分.
  • 这表明OCTA作为VCI的非侵入性诊断工具的潜力.
  • 支持临床决策,以防止ICAS患者的认知衰退.