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临床表现 临床表现

Yi Jin Leow1, Pricilia Tanoto2, Nagaendran Kandiah3

  • 1nil, nil, nil, Nicaragua.

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PubMed
概括
此摘要是机器生成的。

通过MBI-Checklist (MBI-C) 测量轻度行为障碍 (MBI) 症状,预测认知能力下降. 解决MBI症状为认知健康提供了早期干预的机会.

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科学领域:

  • 神经学 神经学
  • 老年学是指老年学的学科.
  • 精神病学是一个精神病学.

背景情况:

  • 微妙的行为变化可能表明早期的认知衰退,提供干预机会.
  • 轻度行为障碍 (MBI) 是认知衰退和阿尔茨海默病 (AD) 的公认前体.
  • MBI-Checklist (MBI-C) 有效地检测到MBI,但由于潜在的文化报告不足,其在东南亚人口中的预测价值需要探索.

研究的目的:

  • 评估纵向MBI-检查表 (MBI-C) 评分是否预测东南亚队列中的认知结果.
  • 评估MBI症状与随后的认知衰退之间的关联.
  • 确定特定的MBI症状领域,这些领域是认知恶化的强烈预测因素.

主要方法:

  • 来自新加坡生物标志物和认知研究 (BIOCIS) 的571名参与者在两次访问中进行了评估,间隔一年.
  • 参与者按认知状态 (正常,主观衰退,MCI,痴呆症) 分类.
  • 用自我报告的MBI-C得分来衡量行为症状,使用线性混合效应模型分析纵向认知结果.

主要成果:

  • 具有临床MBI-C评分的参与者在多个领域显示出较差的基线认知表现.
  • 访问1时MBI-C总得分更高,在访问2时预测认知诊断更差.
  • 访问×MBI-C互动表明,随着时间的推移,MBI-C得分和认知衰退之间的关系越来越强烈,其中"异常信念"显示出最强的关联.

结论:

  • 自我报告的MBI-C得分是早期认知衰退的重要预测因素,验证MBI症状作为临床标志物.
  • 随着时间的推移,MBI对认知的逐渐影响通过加强关联显而易见.
  • "异常信念"子域是认知恶化的一个特别强烈的标志物,突出了MBI在早期干预策略中的作用.