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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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生物标志物 生物标志物

Ran An1

  • 1Peking University, Beijing, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括
此摘要是机器生成的。

在老年人中,认知功能显著影响着步态,尤其是时间成分. 步行速度下降可能表明认知障碍,而时间步行特征是关键预后指标.

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科学领域:

  • 老年学是指老年学的学科.
  • 神经科学是一个神经科学.
  • 生物力学 生物力学

背景情况:

  • 步行性能下降在认知障碍的老年人中很常见.
  • 认知功能对步态的具体影响,超越衰老,需要进一步调查.
  • 了解这种关系对于识别认知衰退的早期标志物至关重要.

研究的目的:

  • 为了检查与老年相关的步行轨迹,跨越痴呆的频谱.
  • 确定认知功能的调解作用在衰老与步态关系中的作用.
  • 确定步态特征作为潜在的认知障碍生物标志物.

主要方法:

  • 在中国 (2022) 进行的观察性队列研究,共有289名参与者 (认知正常,主观认知衰退,认知障碍).
  • 在单任务和双任务条件下使用计算机视觉进行神经心理和步态评估 (空间,时间,空间-时间参数).
  • 与年龄相关的步行轨迹的多项式回归和结构方程建模用于调解分析.

主要成果:

  • 在单任务和双任务条件下,在认知群体中观察到步伐速度的显著差异.
  • 随着年龄的增长,空间和空间时间步态下降;在主观认知衰退和认知障碍组中,时间步态参数随着年龄的增长而增加.
  • 认知功能对空间/空间-时间步行有部分介导的年龄影响,对时间步行有完全介导的影响.

结论:

  • 空间和空间时间步态主要受到正常衰老的影响.
  • 时间步行组件对认知功能下降更为敏感.
  • 步行速度,特别是时间成分,显示出作为认知衰退的非认知生物标志物的潜力.