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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

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此摘要是机器生成的。

TDP-43蛋白病变不同于边缘主导的与年龄相关的TDP-43脑病变 (LATE) 和阿尔茨海默氏病 (AD) 共同病变. 纯LATE显示出明显的TDP-43病变模式,这表明痴呆症中的聚合机制不同.

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科学领域:

  • 神经病理学神经病理学
  • 神经科学是一个神经科学.
  • 老年医学 老年医学

背景情况:

  • 临主导的与年龄相关的TDP-43脑病变 (LATE) 是一种新发现的痴呆病因.
  • 晚期和阿尔茨海默病 (AD) 具有共同的临床症状,并且经常在神经病理上同时发生.
  • 在痴呆症中TDP-43病变形态需要进一步调查.

研究的目的:

  • 调查TDP-43病变形态和纯LATE中的免疫反应性物种,以及在同时存在AD神经病理变化 (ADNC) 的情况下.
  • 在LATE-NC与ADNC+LATE-NC中区分TDP-43蛋白质病变的本病理特征.

主要方法:

  • 70例人体尸检脑组织 (海马体,杏仁体,皮层) 的免疫组织化学分析.
  • 半定量评估TDP-43神经元细胞质内含症 (NCIs) 和变质神经炎 (DNs).
  • 对各种TDP-43物种 (pS409/410,pS409/pS403,pS403/pS404,C-和N-终端TDP-43) 的分析.

主要成果:

  • 纯LATE-NC病例主要表现出海马体中缩神经炎的带状模式.
  • 与ADNC+LATE-NC相比,纯LATE-NC病例在海马体,杏仁体和皮质中具有更严重的缩神经炎负担.
  • 在ADNC+LATE-NC病例中,神经元细胞质内置在杏仁体和独特的TDP-43物种概况中占主导地位.

结论:

  • TDP-43蛋白质病变的组织病理特征在纯LATE-NC和同时存在的ADNC之间有所不同.
  • 晚期NC似乎因ADNC中等至高水平的存在而改变.
  • 不同的机制可能是不同痴呆症TDP-43聚合的基础,同时存在的病理相互影响.