在COVID-19感染后使用基于人工智能的MRI体积测量对大脑体积变化的纵向监测
Zeynep Bendella1,2, Catherine Nichols Widmann2,3, Christine Kindler4,5
1Department of Neuroradiology, Faculty of Medicine, University Hospital Bonn, Rheinische Friedrich-Wilhelm-Universität Bonn, 53127 Bonn, Germany.
Diagnostics (Basel, Switzerland)
|December 30, 2025
概括
康复的COVID-19患者在感染后12个月表现出延迟的右海马缩,特别是在严重疾病后. 其他大脑区域的变化很小,这表明需要对记忆区域进行集中监测.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2 感染与神经系统问题和大脑结构变化有关.
- 以前的研究表明,COVID-19患者的大脑体积减少.
- 关于COVID-19长期神经效应的纵向数据有限.
研究的目的:
- 在康复的COVID-19患者中,在基线MRI后12个月调查大脑体积变化.
- 为了比较轻度/无症状COVID-19,严重COVID-19和对照组之间的纵向大脑体积变化.
- 为了评估COVID-19后神经连续病变的进展.
主要方法:
- 112名参与者 (38名对照组,36名轻度/无症状COVID-19,38名严重COVID-19) 在基线后12个月接受了MRI.
- 基于AI的软件 (mdbrain) 用于大脑区域的体积分析.
- 对人口因素进行控制的多变量回归分析.
主要成果:
- 在COVID-19后12个月观察到右海马体积的显著下降,在严重的COVID-19组中最明显.
- 与对照组相比,在COVID-19组中,正常化的海马体积减少仍然显著.
- 额叶和叶的轻微减少被注意到,但与年龄相关的变化一致,而不是病理进展.
结论:
- 延迟,严重程度依赖的右海马缩发生在康复的COVID-19患者中.
- 对于记忆至关重要的海马体在SARS-CoV-2感染后表现出长期的脆弱性.
- 建议在COVID-19后的患者进行扩展的神经监测,重点关注海马体的完整性.
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