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Updated: Jun 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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作为具有抗癌活性的MMP-13抑制剂的新型Dimethylpyridine-3-Carboxamide衍生物

Remigiusz Płaczek1, Tomasz Janek2, Małgorzata Strzelecka3

  • 1Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.

Molecules (Basel, Switzerland)
|December 31, 2025
PubMed
概括

新的MMP-13抑制剂被合成和测试. 这些化合物显示选择性抑制矩阵金属蛋白酶13 (MMP-13) 和潜在的抗癌活性,提供有前途的治疗途径.

关键词:
MMP-13 抑制剂的使用它具有抗癌活性,具有抗癌活性.二甲基皮里丁-3-碳胺衍生物二甲基皮里丁-3-碳胺衍生物

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Inhibition of Cdk Activity02:34

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...