在向放射性核素治疗中用于剂量预测的半监督学习:一项合成数据研究
Jing Zhang1, Alexandre Bousse2, Chi-Hieu Pham1
1Université de Bretagne Occidentale, 22 Camille Desmoulins, Brest, Brittany, 29238, FRANCE.
Physics in medicine and biology
|January 12, 2026
概括
半监督学习 (SSL) 减少了对深度学习 (DL) 中广泛标记数据的需求,用于在向放射性核素治疗 (TRT) 中预测辐射剂量. 这种方法实现了与完全监督的方法相比的剂量测量精度,即使临床数据有限.
科学领域:
- 医学物理 医学物理
- 放射学 放射学是一门学科.
- 人工智能的人工智能
背景情况:
- 准确的辐射剂量估计对于有效的向放射性核素治疗 (TRT) 是至关重要的.
- 深度学习 (DL) 显示了剂量测量的潜力,但需要大型标记数据集,这些数据集在临床环境中往往是不可用的.
- 这种限制阻碍了TRT中基于DL的剂量计的广泛采用.
研究的目的:
- 开发和评估一个半监督学习 (SSL) 框架,用于TRT中的辐射剂量预测.
- 通过利用现有的治疗前PET数据来减少对大规模标记数据集的依赖.
- 适应和扩展传统的基于分类的SSL方法,用于基于回归的剂量预测.
主要方法:
- 探索一个半监督学习 (SSL) 框架,利用治疗前的PET数据与一小部分剂量标签.
- 调整和扩展基于分类的SSL方法,用于剂量预测中的回归任务.
- 开发一个合成数据集,模拟PET图像和蒙特卡洛剂量计算,用于验证.
主要成果:
- 在不同比例的标记数据下对多重回归适应的SSL方法的评估.
- 在不同器官的剂量预测中,获得的总平均绝对百分比误差为9% - 11%.
- 证明了与完全监督的方法可比的性能.
结论:
- 拟议的SSL方法在TRT中显示了对器官水平剂量预测的有希望的结果.
- SSL有效地解决了基于DL的剂量计有限的标记临床数据的挑战.
- 这种方法提高了TRT个性化剂量计的可行性.
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