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Updated: Jan 14, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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对几种活性化合物的QT数据进行度响应分析

Günter Heimann1, Giulia Lestini2, Jochen Zisowsky3

  • 1Advanced Quantitative Sciences / Pharmacometrics, Novartis Pharma AG, Fabrikstrasse 2, Basel, 4002, Switzerland. guenter.heimann@gmx.de.

Journal of pharmacokinetics and pharmacodynamics
|January 12, 2026
PubMed
概括

这项研究引入了一种新的药物开发方法,联合建模多种活性化合物,以评估它们对纠正的QT (QTc) 间隔的影响. 该方法提供了一个正式的假设测试,以排除5毫秒的QTc效应,改善安全评估.

关键词:
活性代谢物活性代谢物.在 Bootstrap 中使用 Bootstrap.药物组合是一种药物组合.度-QTc分析的分析

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