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相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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相关实验视频

Updated: Jan 16, 2026

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
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A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

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ePerturbDB:增强器的实验性扰动数据库

Samiksha Maurya1, Jaidev Sharma1, Amit Mandoli2

  • 1Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi 110020, India.

Database : the journal of biological databases and curation
|January 15, 2026
PubMed
概括
此摘要是机器生成的。

一个新的数据库,ePerturbDB,列出了83,743个增强器扰动,以确定关键的监管元素. 本资源有助于发现有效的增强剂治疗方法和理解基因调节.

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AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 系统生物学 系统生物学

背景情况:

  • 增强剂是控制基因表达的 cis 调节元件.
  • 干扰增强剂可以改变基因表达和细胞特性,但效果各不相同.
  • 确定治疗向的有效增强剂至关重要.

研究的目的:

  • 创建一个全面的增强器扰动效应数据库.
  • 为识别可有效针对治疗的增强剂提供资源.
  • 帮助理解基因调节和细胞状态的确定.

主要方法:

  • 83,743个实验增强器扰动的汇编.
  • 开发 ePerturbDB 数据库,用于搜索扰动数据.
  • 整合用于比较基因组位置和识别丰富的基因/实体学术语的工具.

主要成果:

  • ePerturbDB提供了一个可搜索的增强器扰动数据库.
  • 用户可以识别扰乱特定基因组位置的潜在影响.
  • 数据库将扰乱增强剂与丰富的基因和本体学术语联系起来.

结论:

  • ePerturbDB是增强器研究的宝贵资源.
  • 该数据库促进了基于增强剂的治疗方法的假设生成.
  • 它有助于推断控制细胞状态的调节机制.