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在头部和部癌症放射治疗期间医疗量身定制的食:试点随机对照试验

Hania M Taha1,2,3, Hannah D Holscher1,4, Fadi Atrash2

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使用碳水化合物限制,高脂肪饮食的医疗定制餐 (MTM) 对接受放射治疗的头癌患者来说是可行的和可以接受的. 这种方法可能有助于保存肌肉,并减少治疗期间的脂肪损失.

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科学领域:

  • 在瘤学瘤学.
  • 营养科学 营养科学
  • 临床试验 临床试验

背景情况:

  • 头癌 (HNC) 患者经常经历体重和肌肉损失.
  • 宏观营养素组成在管理HNC相关缓解症中的作用还未得到充分研究.
  • 放射治疗 (RT) 加剧了HNC患者的营养挑战.

研究的目的:

  • 评估与标准饮食 (SD) 相比,家庭送餐,医疗定制餐 (MTM) 的可行性和可接受性,其中包括碳水化合物限制,高脂肪 (CRHF) 饮食.
  • 在接受RT的新诊断的HNC患者中评估这些饮食.
  • 通过探索体重和身体组成的变化,为未来的试验设计提供信息.

主要方法:

  • 试点随机对照试验与13名HNC患者随机分配到CRHF (n=6) 或SD (n=7) 组.
  • 在RT前两周和RT期间,每天服用同热量MTM.
  • 通过招聘,保留,坚持和接受度评估可行性;探索性身体组成分析.

主要成果:

  • 招聘和保留率分别为65%和69%.
  • 报告的MTM的高度坚持 (92%CRHF,96%SD) 和参与者的满意度.
  • CRHF组显示了较大的肌肉保存和脂肪损失的初步模式.
  • 对任何一种饮食的更高坚持与在RT期间减肥较少相关.

结论:

  • 自宅配送的MTM,包括CRHF配方,在RT期间对HNC患者来说是可行的和可以接受的.
  • "食物是药物"的方法显示出对HNC的营养支持有希望.
  • 需要在更大的试验中进行进一步的研究,以确认在控制体重和身体组成方面的有效性.