Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of DNA Repair02:25

Overview of DNA Repair

33.4K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.4K
Overview of DNA Repair02:25

Overview of DNA Repair

9.6K
9.6K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

10.0K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.0K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

3.0K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.0K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.0K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.0K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.6K
Overview
40.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Controlling scissors during DNA repair of UV light-induced damage.

The Journal of cell biology·2026
Same author

Oxidative base damage to telomeres sensitizes cancer cells to ATR inhibition.

Communications biology·2026
Same author

XPC and global genome nucleotide excision repair are essential for telomere stability after UVC-induced DNA damage in human cells.

DNA repair·2026
Same author

Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer.

Immunity·2026
Same author

Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition.

Cancer research·2026
Same author

Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.

Nature communications·2025

相关实验视频

Updated: Jan 18, 2026

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response
09:39

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Published on: August 2, 2024

899

DNA损伤的表观遗传后果

Tanya T Paull1, Patricia L Opresko2

  • 1Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.

Molecular cell
|January 16, 2026
PubMed
概括

DNA损伤可以产生持久的表观遗传变化,影响基因表达和细胞身份. 这些"表观遗传痕"扩大了我们对基因组稳定性和遗传的理解.

科学领域:

  • 分子生物学分子生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 基因组学就是基因组学.

背景情况:

  • 基因组调节涉及DNA序列和表观遗传机制,如DNA和基因组的修改.
  • DNA损伤可以诱导转录状态的遗传性变化,扩大表观遗传学的范围.
  • 表观遗传传统上侧重于DNA甲基化和基因素修饰.

研究的目的:

  • 审查各种DNA损伤过程如何与表观基因组交叉.
  • 要突出DNA损伤和修复在转录调节和表观遗传遗传中的作用.
  • 探索DNA病变对染色体结构,细胞身份,衰老和疾病的影响.

主要方法:

  • 关于DNA损伤和表观遗传学的科学文献的综述.
  • 对氧化性损伤,R环,端粒损伤,DNA双链断裂和多ADP-ribosylation的分析.
  • 检查DNA损伤,修复和表观遗传修饰之间的相互作用.

主要成果:

  • 氧化DNA损伤和修复显著影响转录调节.
  • R-循环影响基因表达和DNA甲基化动态.
  • 与端粒相关的损伤会影响染色体组织和基因组维护.
关键词:
8oxoGG 8oxoGG是什么意思造成的DNA损伤是DNA损伤.在PARP中,PARP是PARP.在R-Loop中使用.表观遗传学是指表观遗传学.端粒是什么意思 端粒是什么意思

更多相关视频

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

4.1K
Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

10.7K

相关实验视频

Last Updated: Jan 18, 2026

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response
09:39

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Published on: August 2, 2024

899
Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

4.1K
Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

10.7K
  • DNA损伤可以留下持久的表观遗传痕迹,称为"表观遗传痕".

    • 结论:

    • 与DNA损伤相关的过程是表观基因组的关键调节者.
    • 来自DNA损伤的表观遗传痕影响细胞身份,衰老和疾病.
    • 这扩大了对表观遗传和基因组稳定性的理解.