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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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相关实验视频

Updated: Jan 18, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

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癌症SEA-X:瘤单细胞资源 微环境 超过30种癌症类型的细胞状态

Lantian Deng1, Wei Liu1, Jinyuan Xu1

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.

Genomics, proteomics & bioinformatics
|January 17, 2026
PubMed
概括

癌症SEA-X扩展了癌症SEA图谱,详细介绍了来自900多万个细胞的156个瘤微环境 (TME) 细胞状态. 本资源有助于理解癌症异质性和开发新型治疗方法.

关键词:
生物数据库生物数据库癌细胞状态 癌细胞状态单细胞RNA测序的一个细胞.转录的异质性 转录的异质性瘤微环境是一个微环境.

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

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相关实验视频

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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科学领域:

  • 癌症生物学 癌症生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 单细胞研究揭示了癌症中显著的转录和功能异质性.
  • 瘤微环境 (TME) 内的独特的癌症,免疫和 stromal 细胞状态越来越多地被认为具有临床和治疗的重要性.

研究的目的:

  • 介绍CancerSEA-X,这是CancerSEA的扩展版本,提供了TME细胞状态的全面地图.
  • 为已识别的细胞状态提供功能活动光谱和癌症特异性基因关联.
  • 为了提高研究人员探索TME细胞状态及其功能相关性的可用性.

主要方法:

  • 系统的出版物策划,以整合癌症,免疫和 stromal 细胞状态.
  • 汇总了239个单细胞数据集 (来自2120名患者的900多万个细胞) 在32种癌症类型中.
  • 开发一个交互式用户界面用于细胞状态表征,基因相关性分析和网络可视化.

主要成果:

  • 癌症SEA-X集成了25种癌症,105种免疫和26种树皮细胞状态,共计156种不同的TME细胞状态.
  • 为每个细胞状态提供功能活动光谱和基因关联,映射到网络上,以系统地查看TME.
  • 具有改进的用户界面,可以全面探索细胞状态及其功能相关性.

结论:

  • 癌症SEA-X是研究TME细胞状态和癌症异质性的宝贵平台.
  • 有助于更深入地了解瘤微环境中的复杂相互作用.
  • 通过阐明TME细胞状态的作用,有可能推进更有效的临床疗法的设计.