Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Structural Steel Products01:24

Structural Steel Products

634
Structural steel products are created within a structural mill. The process begins with a beam blank that is reheated and then fed through a series of rollers. These rollers progressively shape the metal into its final form. Adjusting the spacings between the rollers allows for the production of different sections with the same nominal dimensions.
Once shaped, the steel's final form emerges as a continuous length, which is then segmented by a hot saw into manageable pieces. These segments...
634
What is Natural Selection?01:32

What is Natural Selection?

126.3K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.3K
Nature and Nurture01:10

Nature and Nurture

22.2K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.2K
The Wave Nature of Light02:12

The Wave Nature of Light

61.0K
The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
61.0K
Chirality in Nature02:30

Chirality in Nature

16.9K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
16.9K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

5.3K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Membrane protein structure and dynamics probed by MicroED.

Biochemical Society transactions·2026
Same author

Discovery of Oxyacanthine Dihydrochloride Monohydrate Polymorphs from Obfuscated Samples by Microcrystal Electron Diffraction.

ChemMedChem·2025
Same author

pH-dependent regulation in SLC38A9.

bioRxiv : the preprint server for biology·2025
Same author

Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines.

Nature chemistry·2025
Same author

The 2024 challenges in structural biology summit.

Structural dynamics (Melville, N.Y.)·2025
Same author

Discovery of oxyacanthine dihydrochloride monohydrate polymorphs from obfuscated samples by MicroED.

bioRxiv : the preprint server for biology·2025

相关实验视频

Updated: Jan 24, 2026

Natural Product Discovery with LC-MS/MS Diagnostic Fragmentation Filtering: Application for Microcystin Analysis
07:18

Natural Product Discovery with LC-MS/MS Diagnostic Fragmentation Filtering: Application for Microcystin Analysis

Published on: May 31, 2019

9.4K

使用MicroED进行自然产品的快速结构分析.

Jieye Lin1, Orel Paz1,2,3, Johan Unge4

  • 1Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, USA.

Small (Weinheim an der Bergstrasse, Germany)
|January 23, 2026
PubMed
概括
此摘要是机器生成的。

微晶电子衍射 (MicroED) 是一种强大的新方法,用于确定复杂的自然产品的3D结构. 这种技术成功地阐明了以前无法通过其他方法实现的结构,即使采用最小的样本量.

关键词:
结晶学 结晶学是指结晶学.微晶电子衍射 (MicroED) 是一种微晶电子衍射技术.自然产品是自然产品的产品.结构分析是结构分析.

更多相关视频

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
11:13

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

11.6K
Generation of Monoclonal Antibodies Against Natural Products
12:15

Generation of Monoclonal Antibodies Against Natural Products

Published on: April 6, 2019

11.6K

相关实验视频

Last Updated: Jan 24, 2026

Natural Product Discovery with LC-MS/MS Diagnostic Fragmentation Filtering: Application for Microcystin Analysis
07:18

Natural Product Discovery with LC-MS/MS Diagnostic Fragmentation Filtering: Application for Microcystin Analysis

Published on: May 31, 2019

9.4K
Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
11:13

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

11.6K
Generation of Monoclonal Antibodies Against Natural Products
12:15

Generation of Monoclonal Antibodies Against Natural Products

Published on: April 6, 2019

11.6K

科学领域:

  • 自然产品化学 自然产品化学
  • 结构生物学 结构生物学
  • 晶体学 晶体学是指结晶学.

背景情况:

  • 复杂的自然产品的结构分析经常受到获得足够高质量的晶体的挑战的阻碍.
  • 像X射线结晶学这样的传统方法需要更大的样本大小和广泛的结晶优化.

研究的目的:

  • 为了证明微晶电子衍射 (MicroED) 对于自然产品结构阐明的可行性和系统应用.
  • 展示MicroED在解决其他方法抵御过的高优先级化合物的结构方面的能力.

主要方法:

  • 微晶电子衍射 (MicroED) 用于分析九种化学上不同的自然产品.
  • 该研究的重点是利用微克的物质量,绕过了大型单晶的需求.

主要成果:

  • 成功确定了九种具有挑战性的自然产品的3D结构,其中许多产品抵御了之前的结构分析.
  • 尽管使用较小的样本数量,但MicroED的成功率与传统方法相比相当.

结论:

  • 微晶电子衍射 (MicroED) 是一种高度有效和高效的工具,用于自然产品的结构阐明.
  • 微ED提供了一种可行的替代方案,用于分析以前被认为无法通过其他结构技术处理的样本.