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相关概念视频

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Design Example: Traverse Angle Computations01:25

Design Example: Traverse Angle Computations

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Traverse angle computations are a critical component of surveying, used to compute the internal angles within a closed traverse. A traverse consists of a series of connected lines forming a closed loop, often used for land boundary delineation or mapping. Calculating the internal angles ensures accuracy in the traverse geometry and is essential for checking survey data integrity.The process begins with known azimuths and bearings of the traverse sides. Internal angles at each vertex are...
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Area Computation by the Alternative Coordinate Method01:24

Area Computation by the Alternative Coordinate Method

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The alternative coordinate method, also known as the Shoelace Formula, is a technique for determining the area of a traverse using Cartesian coordinates. This method relies on the sequential arrangement of x and y coordinates for each point of the shape, ensuring accuracy and ease of application.In this approach, each corner's x and y coordinates are listed as fractions, with the x-coordinate as the numerator and the y-coordinate as the denominator. These coordinates are arranged sequentially...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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Updated: Jan 25, 2026

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导航药物重定位的计算景观.

Andrea Álvarez-Pérez1, Lucía Prieto-Santamaría1, Ana I Casas2,3

  • 1Centro de Tecnología Biomédica and ETS de Ingenieros Informáticos, Universidad Politécnica de Madrid, Madrid, Spain.

Annual review of pharmacology and toxicology
|January 23, 2026
PubMed
概括
此摘要是机器生成的。

药物重新利用为旧药物找到新的用途. 包括人工智能在内的计算方法提供了强大的工具,用于识别这些机会,以更有效地治疗疾病.

关键词:
人工智能的人工智能是人工智能.计算方法的计算方法.药物重新定位 药物重新定位药物重用是为了改变药物的用途.网络医学 网络医学

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 药物重新定位是一种成本效益高的策略,用于识别新的治疗方法.
  • 数据驱动的计算方法在药物重定向研究中越来越重要.
  • 现有的知识库和计算技术为新药发现提供了基础.

研究的目的:

  • 审查用于药物重定向的计算方法.
  • 突出人工智能和大型语言模型在这个领域的作用.
  • 为研究人员提供计算药物重新利用的资源.

主要方法:

  • 分子对接模拟分子对接模拟
  • 基于网络的计算方法.
  • 欧米克斯数据集成数据集成
  • 人工智能和大型语言模型

主要成果:

  • 计算方法为药物重用提供了有价值的见解.
  • 案例研究证明了这些方法的实际应用.
  • 人工智能和LLM正在为识别重用候选人开辟新的途径.

结论:

  • 计算药物重新定位加速了新治疗方法的发现.
  • 多种不同的计算技术的整合增强了重新定位机会的识别.
  • 未来的方向包括利用先进的人工智能来应对药物重用挑战.