Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

What is Gene Expression?01:42

What is Gene Expression?

196.5K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.5K
What is Gene Expression?01:36

What is Gene Expression?

11.4K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.4K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.5K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

5.6K
5.6K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

6.6K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
6.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Study on the influence of cementation sequence on the mechanical properties and microstructure of MICP-modified ili loess.

PloS one·2026
Same author

Contrast-enhanced carotid ultrasound improves vulnerable plaque detection in acute central retinal artery occlusion: a propensity score-matched study.

Frontiers in cardiovascular medicine·2026
Same author

Label-free histopathological diagnosis of frozen sections based on multi-excitation and broad-emission autofluorescence imaging.

Biomedical optics express·2025
Same author

Microenvironment-Activatable Long-Wavelength NIR-II Visualization and Synergistic Treatment of Pulmonary Embolism.

ACS nano·2025
Same author

<i>Enterococcus faecalis</i> hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn's disease by inducing gut dysbiosis.

Gut·2025
Same author

Designing a 3-Hydroxypropane-1-Sulfonate Deep-Ultraviolet Nonlinear Optical Crystal.

Small (Weinheim an der Bergstrasse, Germany)·2025

相关实验视频

Updated: Jan 29, 2026

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
10:34

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

Published on: April 14, 2010

16.0K

HFFST:一个层次特征融合算法用于空间基因表达预测,使用组织病理学图像.

Yue Wang, Yanan Li, Changjiang Zhou

    IEEE transactions on computational biology and bioinformatics
    |January 27, 2026
    PubMed
    概括
    此摘要是机器生成的。

    从病理图像中预测空间基因表达对于疾病研究至关重要. 一个新的层次特征融合算法 (HFFST) 有效地利用图像细节来改进空间转录基因预测,提供一个具有成本效益的替代方案.

    更多相关视频

    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
    11:53

    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

    Published on: December 9, 2012

    13.4K
    Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
    11:52

    Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

    Published on: February 9, 2017

    6.5K

    相关实验视频

    Last Updated: Jan 29, 2026

    Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
    10:34

    Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

    Published on: April 14, 2010

    16.0K
    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
    11:53

    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

    Published on: December 9, 2012

    13.4K
    Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
    11:52

    Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

    Published on: February 9, 2017

    6.5K

    科学领域:

    • 计算生物学是一种计算生物学.
    • 数字病理学数字病理学
    • 基因组学就是基因组学.

    背景情况:

    • 空间转录学促进了疾病理解和个性化医疗,但面临成本和复杂性的障碍.
    • 从H&E图像中预测空间基因表达提供了一个有希望的,更容易获得的替代方案.
    • 现有的方法往往忽视了病态图像信息的等级性质.

    研究的目的:

    • 开发和验证一种新的层次特征融合算法 (HFFST),用于从H&E染色病理图像中预测空间基因表达.
    • 为了提高空间转录基因概况预测的准确性和实用性,使用基因病理学数据.
    • 通过利用多层次图像功能来解决当前方法的局限性.

    主要方法:

    • 开发了HFFST,这是一个层次化的特征融合算法,集成了从整个幻灯片图像中提取多层次特征.
    • 采用粗微回归框架来预测空间转录组形状.
    • 通过对五个公共数据集进行交叉验证和使用高分辨率Visium数据进行外部验证来验证HFFST.

    主要成果:

    • 在预测空间基因表达特征方面,HFFST表现出强的表现.
    • 该算法成功地在病理图像中识别了不同的空间区域.
    • 在预测空间转录基因数据方面,HFFST显示了与现有的最先进方法相比的优势.

    结论:

    • HFFST提供了一种有前途的方法,可以从H&E图像中预测空间基因表达,克服当前技术的局限性.
    • 该方法增强了将数字病理学与转录组数据集成为生物医学研究的潜力.
    • HFFST为推进疾病机制研究和治疗点发现提供了宝贵的工具.