相关实验视频
Updated: Jan 29, 2026

07:42
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
496
食纤维和黑色素瘤:探索微生物驱动的免疫调节
Laci Turner1, Connor K Sisk1, Nabiha Yusuf2
1Heersink School of Medicine, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35233, USA.
Cancers
|January 28, 2026
概括
食纤维摄入量可以通过调节肠道微生物群来增强黑色素瘤免疫疗法. 富含纤维的饮食和特定的肠道细菌与更好的免疫检查点抑制剂反应和更好的生存率有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物组显著影响黑色素瘤的发展和对免疫检查点抑制剂 (ICI) 的反应.
- 食纤维是影响肠道微生物组成和代谢物生产的关键可改变因素.
- 了解纤维的作用是优化黑色素瘤治疗结果的关键.
研究的目的:
- 审查有关食纤维如何影响黑色素瘤免疫力和治疗的机械学,临床前和临床证据.
- 探索富含纤维的饮食和特定肠道细菌对黑色素瘤免疫疗法的影响.
- 为黑色素瘤患者确定潜在的基于纤维的干预措施.
主要方法:
- 在MEDLINE,Embase和Scopus进行了全面的文献搜索,寻找过去五年内的研究.
- 选了491个独特的记录,并对49个相关的同行评审研究进行了定性合成.
- 该审查包括机理学,临床前,观察和干预研究.
主要成果:
- 纤维发酵产生短链脂肪酸,调节免疫细胞功能和细胞因子信号传递.
- 临床前模型显示,纤维以微生物群依赖的方式增强抗瘤免疫力和ICI疗效.
- 在人类中,纤维摄入量和特定的细菌 (例如,Bifidobacterium,Faecalibacterium,Akkermansia) 与更好的ICI反应,更长的存活时间和减少结肠炎相关.
结论:
- 食纤维显示出作为黑色素瘤免疫治疗的安全辅助疗法的承诺.
- 进一步的受控试验是必要的,以确定因果关系和优化纤维干预措施,由于研究变化和相互矛盾的数据.
相关概念视频
Dietary Connections
61.7K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
61.7K
Proteins: Dietary Sources and Requirements
1.7K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.7K
What is the Immune System?
127.6K
Overview
127.6K
Carbohydrates: Dietary Sources and Requirements
1.7K
Carbohydrates are predominantly obtained from plant sources. With the exception of lactose found in milk and insignificant glycogen amounts in meat, most consumed carbohydrates have plant origins. Monosaccharides and disaccharides, or sugars, can be sourced from fruits, honey, milk, sugar cane, and sugar beets. Grains and vegetables are rich in the polysaccharide starch. Two types of polysaccharides provide fiber: cellulose, which is abundant in many vegetables, forms undigestible roughage or...
1.7K
Lipids: Dietary Sources and Requirements
1.9K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
1.9K
Classification of Skeletal Muscle Fibers
59.5K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.5K

