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死亡性肠球炎生物标志物:系统性审查
Muhammad Ashhad Faizan1,2, Iffat Khalid1, Asten Yeo1
1Department of Paediatrics, University of Dublin, Trinity College, Dublin, Ireland.
Frontiers in pediatrics
|January 28, 2026
概括
结核性肠球炎 (NEC) 的诊断是具有挑战性的. 本综述确定了像calprotectin和特定尿蛋白这样的生物标志物,这些生物标志物在早产新生儿中对早期NEC检测具有很高的准确性.
科学领域:
- 新生儿医学 新生儿医学
- 胃肠病学 胃肠病学
- 生物标志物研究 生物标志物研究
背景情况:
- 死性肠球炎 (NEC) 是一种严重的胃肠炎症疾病,会影响早产婴儿.
- 诊断中的困难源于可变的临床症状和缺乏标准化的生物标志物.
- 了解炎症途径对于早期检测和管理至关重要.
研究的目的:
- 审查NEC病变发生过程中的炎症途径.
- 为了确定早期NEC检测的潜在生物标志物.
- 评估已识别的生物标志物的诊断准确性.
主要方法:
- 在PubMed,Embase和Cochrane数据库中的系统文献搜索.
- 包括专注于NEC生物标志物的诊断准确性的研究.
- 使用QUADAS-2工具评估偏差风险,按照PRISMA指南进行评估.
主要成果:
- 分析了79项研究,评估了区分NEC阶段的生物标志物.
- 便和血清calprotectin显示出高灵敏度和特异性.
- 尿蛋白面板 (CST3,PEDF,RET4) 和DSNLT也显示出有希望的诊断准确性.
结论:
- 一些生物标志物,包括calprotectin和特定的尿蛋白,显示出早期NEC诊断的潜力.
- 需要进一步的研究来验证这些生物标志物在临床实践中.
- 准确的早期检测可以改善NEC的早产新生儿的结果.
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