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Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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截听:肠道神经系统进入聊天.
Kelly L Buchanan1, Rachel L Wolfson1
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Current biology : CB
|February 3, 2026
概括
内在的肠道神经元,通常调节肠道功能,也可能启动互感信号. 这挑战了传统的观点,即只有背部根结节感觉神经元才能处理肠道感觉信息.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 这是一种内在的感觉.
背景情况:
- 内在肠道神经元 (ENs) 控制肠道功能,如运动,分泌和吸收.
- 外在的背部根 (DRG) 感觉神经元主要被认为是介导结肠内感受和内脏疼痛感知.
研究的目的:
- 为了研究肠道神经元在启动结肠内感官信号中的潜在作用.
- 探索一种除背部根结核之外的内脏感官信息的替代来源.
主要方法:
- 这项研究可能涉及肠道神经系统的体内或体外模型.
- 电生理学记录或神经元追踪技术可能被用来评估神经元活动和连接性.
主要成果:
- 初步发现表明,肠道神经元可能有助于初始处理全感应信号.
- 这表明ENs在感官路径中的潜在重叠或新功能.
结论:
- 肠道神经元可能在肠道内接中发挥着比以前理解的更重要的作用.
- 这项研究为了解内脏感觉和疼痛机制开辟了新的途径.

