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相关概念视频

Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Balancing Redox Equations02:58

Balancing Redox Equations

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Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
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General Anesthesia: Overview01:24

General Anesthesia: Overview

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Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
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Stages of General Anesthesia01:22

Stages of General Anesthesia

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Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
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Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

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Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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相关实验视频

Updated: Feb 6, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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探索全身麻醉期间的感觉-止痛平衡和EEG调节模式,使用Holo-Hilbert光谱分析.

Chun-Ning Ho1,2,3, Norden E Huang1, Jen-Yin Chen2,3

  • 1Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan, nctu.edu.tw.

Pain research & management
|February 5, 2026
PubMed
概括

霍罗-希尔伯特光谱分析 (HHSA) 揭示了麻醉期间多层次的大脑波调制. 这种EEG分析可以监测痛感 (疼痛) 和止痛,改善患者的护理.

关键词:
霍洛-希尔伯特光谱分析手术填充指数的指数一个电脑电图 (electroencephalogram) 是一个电脑电图.一般麻醉全身麻醉无感性止痛平衡的平衡.

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Electrophysiological Measurements and Analysis of Nociception in Human Infants
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相关实验视频

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Electrophysiological Measurements and Analysis of Nociception in Human Infants
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Applications of EEG Neuroimaging Data: Event-related Potentials, Spectral Power, and Multiscale Entropy
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科学领域:

  • 神经科学是一个神经科学.
  • 麻醉学 麻醉学
  • 信号处理 信号处理

背景情况:

  • 术内脑电图 (EEG) 提供了对麻醉期间大脑活动的非侵入性洞察.
  • 传统的EEG频谱分析难以检测与疼痛处理相关的动态调制模式.
  • 在麻醉下进行知觉处理需要先进的分析技术来进行准确的监测.

研究的目的:

  • 应用Holo-Hilbert光谱分析 (HHSA) 来描述在全身麻醉期间EEG的交叉频率调制.
  • 为了研究这些EEG调制模式与外科术位指数 (SPI) 之间的关系,以此来衡量 nociception.
  • 识别潜在的EEG标记物,用于实时的感觉监测.

主要方法:

  • 使用HHSA分析了134名接受妇科手术的女性患者的EEG数据.
  • HHSA将EEG信号分解成广度调制模式,跨越广泛的频率范围 (1/64-64 Hz).
  • 调制模式与SPI,最小膜度 (MAC),心率 (HR) 和平均动脉压 (NIBP-m) 相比进行了分析.

主要成果:

  • 在阿尔法载波波段 (8-16 Hz) 确定了两个主导的交叉频率相互作用,由三角形 (1-6 Hz) 和 Θ (3-8 Hz) 振荡调节.
  • 在 nociceptive 状态 (SPI > 60) 中,α 波段和高-delta 波段的调制功率增加,而 θ 波段和低-delta 波段的调制功率下降.
  • 阿尔法频段调制功率与SPI正相关,与MAC负相关.

结论:

  • HHSA有效地揭示了明显的交叉频率调制模式,反映了 nociception 和止痛之间的平衡.
  • 通过HHSA识别的α频段调制作为一个有希望的,生理上接地EEG标记器.
  • 这种方法可以在全身麻醉期间进行个性化的感觉监测.