基于微生物群的干预不同地拯救了Drosophila自闭症样模型中的肠道和社会行为表型
bioRxiv : the preprint server for biology
|February 6, 2026
概括
中的KDM5基因突变会导致肠道疾病和社会缺陷. 虽然一些益生菌恢复了肠道细菌,但只有特定的菌株,如Lactobacillus helveticus改善了社会行为,突出了自闭症谱系障碍中肠-大脑通信的复杂性.
科学领域:
- 神经科学和微生物学
- 表观遗传学和肠-大脑轴研究
- 模型生物研究 (Drosophila) 的研究.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种终身的神经发育障碍,通常与胃肠道 (GI) 问题有关.
- 肠道微生物群-大脑轴与肠道功能障碍有关,有助于ASD的神经症状.
- 在KDM5基因组脱甲基酶中的功能丧失突变与智力障碍和自闭症有关.
研究的目的:
- 评估基于微生物群的干预措施 (益生菌,FMT) 调节肠道微生物群和行为,在Drosophila KDM5功能丧失 (KDM5LOF) 模型.
- 研究KDM5在调节肠道微生物组成和社会行为的作用.
- 为了确定恢复肠道微生物丰富程度是否足以挽救行为缺陷.
主要方法:
- 使用Drosophila KDM5LOF模型展示了类似ASD的表型.
- 服用益生菌补充剂 (Lactiplantibacillus plantarum, Lactobacillus helveticus) 并进行了便微生物群移植 (FMT).
- 通过CFU测定和16SrRNA基因测序量化细菌丰度;评估社会行为,焦虑和运动.
主要成果:
- 缺乏KDM5导致肠道乳杆菌,菌和肠杆菌物种减少,社会行为受损.
- L. plantarum恢复了肠道微生物的丰富性,但没有恢复社会行为;L. helveticus改善了社会互动,但没有显著改变细菌的丰富性.
- 便微生物群移植部分恢复了Lactobacillus,重塑了微生物群落,并改善了KDM5LOF的社会行为.
结论:
- KDM5是肠道微生物生存能力和社会行为的关键调节者.
- 基于微生物群的干预措施具有特定于菌株和表型的效应;单独的微生物恢复不足以拯救社会行为.
- 果虫可以作为一个有价值的模型来研究与ASD相关的微生物群-行为关系的表观遗传调节.
相关概念视频
Social Scripts
10.3K
People tend to know what behavior is expected of them in specific, familiar settings. A script is a person’s knowledge about the sequence of events expected in a specific setting (Schank & Abelson, 1977). Essentially, scripts are a particular kind of schema, one containing default values for the features within an event. In the restaurant example, the script's features include the props (e.g., tables, menu, food, and money), the roles to be played (e.g., customer and waiter),...
10.3K
Community Based Intervention
483
Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
483
Social Psychology and Individual Behavior
319
Social psychology examines how group dynamics, emotions, and cultural influences shape individual actions and decision-making. These elements interact to form behavioral patterns that affect personal choices and social interactions.The Role of Group DynamicsGroups play a crucial role in shaping behavior by reinforcing norms and expectations. Individuals derive a sense of self from group membership, often aligning their behaviors with group norms to maintain social cohesion. For example, an...
319
Causes of Social Behavior II: Cognitive Processes
206
Cognitive processes affect social behavior by guiding how individuals perceive, interpret, and respond to social stimuli. These mental processes enable individuals to assess others' behaviors, attribute causes to their actions, and form expectations based on past experiences.Causes of Behavior and Social JudgmentsIndividuals determine the causes of others' behaviors by distinguishing between personal traits and external circumstances. For example, if a friend frequently arrives late, an...
206
Social Proof
32.4K
Social proof is a form of persuasion based on comparison and conformity. People compare their behavior and actions to what others are doing and will change to conform to do what their peers do.
32.4K
Causes of Social Behavior I: Actions and Characteristics of Individuals
356
The actions and characteristics of others heavily influence the causes of social behaviors. Emotional expressions serve as powerful social signals, shaping behaviors and interactions in significant ways. Whether through direct observation or subconscious processing, individuals constantly adjust their responses based on the emotions and attributes of those around them.Emotional Cues and Social ResponsesFacial expressions, tone of voice, and body language provide crucial emotional cues that...
356


